Health-related quality of life (HRQL) is a multidimensional construct that quantifies outcomes of health status, functional status and the subjective experience of an individual, into a single summary measure. Understanding the associations between common chronic conditions and HRQL impairments is useful for providers and policy makers in targeting and evaluating interventions toward selected populations at risk of poor HRQL. This is particularly relevant in the home care sector, which is typically comprised of vulnerable older adults with multiple chronic conditions who are often at heightened risk of functional decline.